Discovery Projects - Grant ID: DP210101496

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210101496

Funding Status
Active

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Funded Activity Summary

Sulfoxide Polymers - A New Paradigm in Polymer Design. Low fouling polymers are important for moderating interactions of molecules and particles with cells. In pharmaceutical sciences they are essential tools for extending the pharmacokinetics of dissolved drugs. However, the widely-used low-fouling polymer, poly(ethylene glycol) (PEG) has been recently reported to induce formation of anti-PEG antibodies. Polymeric alternatives to PEG are thus desperately needed. We introduce in this project super-hydrophilic polymers incorporating sulfoxide groups, mimics of the polar solvent DMSO. The project aims to explore how polymer architecture can enhance biocompatibility and reduce biofouling. The outcome will be a new class of low-fouling polymeric materials with broad application in the biosciences.

Funded Activity Details

Start Date: 01-05-2021

End Date: 30-04-2024

Funding Scheme: Discovery Projects

Funding Amount: $472,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Physical Chemistry of Materials | Macromolecular and Materials Chemistry | Synthesis of Materials | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biologically Active Molecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Macromolecular and Materials Chemistry | Physical Chemistry of Materials | Synthesis of Materials

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