Discovery Projects - Grant ID: DP210101416

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210101416

Funding Status
Active

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Funded Activity Summary

Understanding the life and death of Mucosal-associated invariant T cells. Cell death of naïve T cells in lymphoid organs is well-understood. However, T cells only gain their function upon activation, and how activated T cells regulate their life or death remains unclear. Mucosal-associated Invariant T (MAIT) cells are abundant in non-lymphoid tissues as key local players in immunity, and share some features of activated conventional T cells. This project aims to define how MAIT cell survival and death are controlled. It combines methods we developed to track MAIT cells in vivo with expertise in cell death analysis. This project is expected to elucidate the complex mechanisms controlling MAIT cell survival/death and increase our fundamental understanding of cell death mechanisms of activated T cells.

Funded Activity Details

Start Date: 01-01-2021

End Date: 31-12-2023

Funding Scheme: Discovery Projects

Funding Amount: $434,588.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Agents | Cellular Immunology | Immunology | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Immune System and Allergy | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Cell Development, Proliferation and Death | Cellular Immunology | Expanding Knowledge in the Medical and Health Sciences | Immune System and Allergy | Immunology | Infectious Agents

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