Discovery Projects - Grant ID: DP210100393

Funding Activity

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Funded Activity Summary

Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus to alter stem cell aging and fate. The findings will provide critical information required for the future development of assays to measure cell potency and instructive biomaterials to drive stem cell expansion and tissue-regeneration and will have impact by underpinning future advances in stem cell technologies.

Funded Activity Details

Start Date: 01-01-2021

End Date: 30-06-2024

Funding Scheme: Discovery Projects

Funding Amount: $413,000.00

Funder: Australian Research Council