Discovery Projects - Grant ID: DP200103110

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200103110

Funding Status
Active

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Funded Activity Summary

Antigen selection mechanisms control T cell immunity against bacteria. CD4+ T (T helper) cells are required to control many important bacterial infections. This Project aims to identify the key targets of CD4+ T cells responding to a model bacterial infection, and to correlate potential antigen effectiveness with native expression, antigen presentation, and the function of antigen-specific CD4+ T cells over time. Our validated experimental 'pipeline' has unprecedented potential to define potent CD4+ T cell antigens within the thousands of proteins expressed by a bacterial pathogen. Our unbiased analysis may help establish the rules that define effective antigenicity. Our work will improve the understanding of bacterial immunity, and inform future design of T-cell based vaccines in the agricultural sector.

Funded Activity Details

Start Date: 01-09-2020

End Date: 31-12-2023

Funding Scheme: Discovery Projects

Funding Amount: $587,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Immunology | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy |

Other Keywords

Bacteriology | Cellular Immunology | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Immunology

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