Discovery Projects - Grant ID: DP200102776

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200102776

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Exceptions Prove the Rule: How Antigen Recognition Drives T cell Activation. CD8+ T cells are immune cells that are critical for the adaptive immune response, which is central to immune function in vertebrates. CD8+ T cells mediate their effector functions only after activation, which occurs via T cell receptor (TCR) recognition of foreign antigens. Here, unique reagents and sophisticated technologies will be used to define precisely how the nature of TCR-antigen recognition impacts on T cell activation and effector function. This work builds on an earlier identification of an entirely novel mode of TCR-antigen recognition, and its success will establish novel paradigms in T cell biology and represent a key advance in knowledge in the life sciences.

Funded Activity Details

Start Date: 01-01-2020

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $590,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Signal Transduction | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Receptors and Membrane Biology | Signal Transduction | Structural Biology (incl. Macromolecular Modelling)

Related Links