Discovery Projects - Grant ID: DP200102540

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200102540

Funding Status
Closed

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Funded Activity Summary

Structural basis of gating in hERG potassium ion channel proteins. This project aims to use cryo-electron microscopy to determine atomic resolution structures of open, closed and inactivated states of an ion channel important for regulating activity in the heart and the brain. This work will provide fundamental insights into how ion channel proteins utilise electrochemical energy to mechanically open and close gates that regulate ion flow across cell membranes. Electrical signalling is ubiquitous in biology but is of particular importance in the brain and heart where ion channels are important therapeutic targets for cardiovascular and psychiatric diseases.

Funded Activity Details

Start Date: 01-01-2020

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $477,513.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) |

Other Keywords

Biochemistry and Cell Biology | Cardiovascular System and Diseases | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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