Discovery Projects - Grant ID: DP200102377

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200102377

Funding Status
Closed

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Funded Activity Summary

Toxins from Down Under: Novel tools to understand and modulate ion channels. Venoms are complex secretions containing biologically active components that have evolved over millions of years to specifically target the nervous systems of predators and prey. Two novel classes of toxins from snake and plant venoms that act on voltage-gated sodium channels, key proteins that regulate neuronal excitability, were recently identified by the research team. The project aims to develop and apply state-of-the-art chemical, structural and biological techniques to unravel the molecular mechanisms through which these novel toxin classes act at their targets. Insights gained from this project will help identify and develop novel channel-modulating molecules that may have applications as neuroscience tools, diagnostics or drugs.

Funded Activity Details

Start Date: 01-01-2020

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $390,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Medicinal and Biomolecular Chemistry | Receptors and Membrane Biology | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biologically Active Molecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry | Proteins and Peptides | Receptors and Membrane Biology

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