Discovery Projects - Grant ID: DP200102363

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200102363

Funding Status
Closed

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Funded Activity Summary

Control of cellular differentiation in the developing brain. This project aims to understand how mature brain cells form during foetal life. The central hypothesis is that a specific transcription factor family, called NFI, regulates the epigenetic state of the cell, allowing chromatin accessibility and subsequent transcriptional activation and repression to control cellular differentiation. Aims 1 and 2 will investigate how brain cells transition from proliferating progenitor cells to differentiated mature cell types. Aim 3 will investigate how differentiation is maintained in the adult brain. Methods used involve genome and chromatin analyses of cells isolated from transgenic mouse models. Outcomes and benefits are substantial knowledge gain applicable to stem cell regulation and brain health.

Funded Activity Details

Start Date: 01-01-2020

End Date: 31-01-2022

Funding Scheme: Discovery Projects

Funding Amount: $615,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System | Neurosciences

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Central Nervous System | Expanding Knowledge in the Biological Sciences | Neurosciences

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