Discovery Projects - Grant ID: DP200101970

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200101970

Funding Status
Active

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Funded Activity Summary

Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.

Funded Activity Details

Start Date: 18-12-2020

End Date: 31-12-2023

Funding Scheme: Discovery Projects

Funding Amount: $469,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biomechanical Engineering | Biomedical Engineering | Fluidisation and Fluid Mechanics

ANZSRC Socio-Economic Objective (SEO)

Scientific Instruments | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology |

Other Keywords

Biomechanical Engineering | Biomedical Engineering | Expanding Knowledge in Technology | Expanding Knowledge in the Biological Sciences | Fluidisation and Fluid Mechanics | Scientific Instruments

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