Discovery Projects - Grant ID: DP200101874

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200101874

Funding Status
Active

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Funded Activity Summary

Peril and promise: Origins and spread of integron gene cassettes. Integrons have a major role in spreading antibiotic resistance genes among pathogens. They do so by capturing gene cassettes encoding resistance, yet how these cassettes are generated, the taxa in which they originate, and the range of traits that cassettes can encode have been outstanding questions for 30 years. This project addresses these long standing questions. The project will analyze single bacterial cells to detect newly generated cassettes and assign them to specific taxa, using an innovative method that links cassette DNA to bacterial 16S rDNA. Understanding cassette origins is the key to controlling their activity, both to harness integrons for biotechnology, and to prevent pathogens from acquiring new, dangerous traits.

Funded Activity Details

Start Date: 13-11-2020

End Date: 12-11-2023

Funding Scheme: Discovery Projects

Funding Amount: $530,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Microbial Genetics | Microbial Ecology | Microbiology |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Infectious Diseases

Other Keywords

Expanding Knowledge in the Biological Sciences | Infectious Diseases | Microbial Ecology | Microbial Genetics | Microbiology

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