Discovery Projects - Grant ID: DP200101860

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200101860

Funding Status
Active

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Funded Activity Summary

A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To understand how the method can be optimized, the thermodynamic pathway of membrane disruption will be investigated at a single cell level. The methods and insights arising from this project could eventually lead to novel, patentable and lower-cost health technologies.

Funded Activity Details

Start Date: 06-07-2020

End Date: 05-11-2023

Funding Scheme: Discovery Projects

Funding Amount: $505,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology - Biophysics | Animal Physiology - Cell | Physiology | Microtechnology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences |

Other Keywords

Animal Physiology - Biophysics | Animal Physiology - Cell | Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences | Microtechnology | Physiology

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