Discovery Projects - Grant ID: DP200101138

Funded Activity Summary

Ancestral, conserved and novel mechanisms in marsupial genomic imprinting. Genomic imprinting is the differential expression pattern of some genes depending on whether the gene copy came from the mother or the father. This differential expression is essential for embryonic development and errors lead to disease. To date, most of our knowledge of the control of genomic imprinting comes from the mouse, but much less is known about this process in marsupials. Our comparative approach, using marsupial mammals that are distantly related to mice and humans, aims to clarify how genomic imprinting mechanisms have evolved, which patterns are conserved across mammals, and which vary. Our proposed research aims to provide new approaches and understanding of this fundamental process essential for the continuation of life.

Funded Activity Details

Start Date: 07-07-2020

End Date: 06-07-2025

Funding Scheme: Discovery Projects

Funding Amount: $1,023,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Evolution of Developmental Systems | Epigenetics (incl. Genome Methylation and Epigenomics) | Reproduction | Genetics

ANZSRC Socio-Economic Objective (SEO)

Reproductive System and Disorders | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Epigenetics (incl. Genome Methylation and Epigenomics) | Evolution of Developmental Systems | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Genetics | Reproduction | Reproductive System and Disorders

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