Discovery Projects - Grant ID: DP200100860

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200100860

Funding Status
Active

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Funded Activity Summary

Force-from-lipids biophysical principle underlying mechanotransduction. The major aim of this project is to determine evolutionary conserved physical principles of mechanotransduction in living cells through structure and function studies of PIEZO mechanoreceptor channels playing a crucial role in senses such as touch and pain in animals and humans. Mutations in these channels can cause numerous genetic disorders, including hereditary anaemias and joint contractures. Since they have been shown to respond to mechanical stimuli in the same manner as mechanoreceptor channels of organisms from bacteria to humans the intended outcome of this project is to uncover the unifying principles of mechanotransduction anchored in the laws of physics and chemistry that have guided the force-dependent design of all life forms.

Funded Activity Details

Start Date: 01-01-2020

End Date: 31-12-2023

Funding Scheme: Discovery Projects

Funding Amount: $860,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Education and Training Theory and Methodology | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Education and Training Theory and Methodology | Expanding Knowledge in the Biological Sciences | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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