Discovery Projects - Grant ID: DP200100348

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200100348

Funding Status
Active

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Funded Activity Summary

New methods for drug discovery by NMR spectroscopy. This project aims to advance nuclear magnetic resonance (NMR) spectroscopy methods in the field of drug discovery. It addresses a long-standing bottleneck for medicinal chemists in drug development: the rapid determination of how ligand molecules bind to proteins, where they bind and their orientation in the binding site. The methods include techniques for the attachment of NMR tags to ligands and target proteins, installation of new unnatural amino acids in proteins, and software for automated assignment of NMR spectra and 3D structure modelling of proteins using sparse distance restraints measured by electron paramagnetic resonance (EPR) spectroscopy. The outcome is to benefit the early stages of drug discovery in the biotech industries.

Funded Activity Details

Start Date: 23-03-2020

End Date: 22-03-2023

Funding Scheme: Discovery Projects

Funding Amount: $526,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Organic Chemical Synthesis | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Application Software Packages (excl. Computer Games) |

Other Keywords

Application Software Packages (excl. Computer Games) | Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Organic Chemical Synthesis | Structural Biology (incl. Macromolecular Modelling)

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