Discovery Projects - Grant ID: DP190103634

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190103634

Funding Status
Active

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Funded Activity Summary

How the red blood cell loses its nucleus. This project aims to provide insights into erythroid enucleation, the process by which red blood cells extrude their nucleus so that they can circulate through the microvasculature. Although the enucleated character of mammalian red blood cells has been known for more than 150 years, the mechanism underlying this process is virtually unknown. This project will use a live imaging approach to characterise in vivo the cellular interactions and molecular pathways required for enucleation. The project will provide a molecular and cellular road map of enucleation that may be utilised to enhance the bulk therapeutic in vitro production of red blood cells for veterinary and human purposes.

Funded Activity Details

Start Date: 01-09-2019

End Date: 31-12-2023

Funding Scheme: Discovery Projects

Funding Amount: $507,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Haematology | Radiology and Organ Imaging | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Cell Development, Proliferation and Death | Expanding Knowledge in the Biological Sciences | Haematology | Radiology and Organ Imaging

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