Discovery Projects - Grant ID: DP190103282

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190103282

Funding Status
Active

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Funded Activity Summary

Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognition mechanisms.

Funded Activity Details

Start Date: 17-04-2019

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $361,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) | Immunology | Immunogenetics (incl. Genetic Immunology)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy |

Other Keywords

Cellular Immunology | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Immunogenetics (incl. Genetic Immunology) | Immunology | Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)

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