Discovery Projects - Grant ID: DP190103158

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190103158

Funding Status
Closed

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Funded Activity Summary

Molybdenum enzyme electrochemical communication. This project aims to understand the activity of three novel, but related, molybdenum enzymes, human mARC and its bacterial homologs YcbX and YiiM. The role of mARC in humans remains unknown twelve years after its discovery. All three enzymes catalyse the reduction of potentially harmful N-hydroxylated compounds and there is interest in this area from the perspective of drug design. This project will apply an electrochemical methodology to rapidly identify enzyme substrates and inhibitors. Molybdenum enzymes pervade all life forms and the outcomes of this research include a unified understanding of an emerging enzyme class involved in drug metabolism.

Funded Activity Details

Start Date: 01-02-2019

End Date: 30-06-2022

Funding Scheme: Discovery Projects

Funding Amount: $351,142.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Electrochemistry | Inorganic Chemistry | Bioinorganic Chemistry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences |

Other Keywords

Bioinorganic Chemistry | Electrochemistry | Expanding Knowledge in the Chemical Sciences | Inorganic Chemistry

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