Discovery Projects - Grant ID: DP190102789

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190102789

Funding Status
Closed

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Funded Activity Summary

Regulation of mRNA translation by the microtubule-associated protein Tau. This project aims to understand the molecular processes in a cell type and subcellular compartment that underlies learning and memory formation. Fundamental neuronal functions such as synaptic strengthening and memory formation are dependent on the tightly regulated process of protein translation. The kinase Fyn (which is localised to dendritic spines where memories are formed) activates the ERK/S6 pathway leading to massive translation of the scaffolding protein Tau. More importantly, the activation of this cascade is Tau-dependent. This project aims to determine how Tau activates this pathway, and to decipher the physiological role of the Tau/Fyn/Tau feedback loop. This will inform our understanding of the molecular regulation of learning and memory.

Funded Activity Details

Start Date: 10-01-2019

End Date: 09-01-2022

Funding Scheme: Discovery Projects

Funding Amount: $464,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System | Biochemistry and Cell Biology | Signal Transduction | Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Cell Neurochemistry | Cellular Nervous System | Expanding Knowledge in the Biological Sciences | Signal Transduction

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