Discovery Projects - Grant ID: DP190102704

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190102704

Funding Status
Active

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Funded Activity Summary

Lifespan-dependent molecular shaping of the T cell receptor repertoire. Mammals have an intricate and highly complex immune system, whose function alters throughout life. Why and how this occurs is very unclear however, yet remains a crucial question. This project aims to provide fundamental knowledge on how the human lifespan shapes specific T cell receptors and determine molecular mechanisms underlying gain-of-function and loss-of-function during immunologically distinct phases of life. This project will provide analysis of multi-dimensional, high throughput datasets to identify fundamental links between the transcriptional landscape and TCR signatures across human lifespan, thus will significantly answer key immunological questions in the field.

Funded Activity Details

Start Date: 11-02-2019

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $575,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Systems Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Health not elsewhere classified | Immune System and Allergy |

Other Keywords

Biochemistry and Cell Biology | Cellular Immunology | Expanding Knowledge in the Biological Sciences | Health not elsewhere classified | Immune System and Allergy | Structural Biology (incl. Macromolecular Modelling) | Systems Biology

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