Discovery Projects - Grant ID: DP190102509

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190102509

Funding Status
Active

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Funded Activity Summary

Thioamide ligations: new technologies for peptide and protein synthesis. This project aims to develop novel amide-bond forming reactions for the chemical synthesis of peptides and proteins. New peptide ligation strategies, including an asparagine-based ligation and a residue-independent ligation will be developed that exploit the recent discovery of silver-promoted coupling reactions of thioamides. A novel late-stage, chemo-selective assembly of N-glycosylated asparagine residues in peptides and proteins will also be developed. The outcomes of this research will lead to breakthroughs in synthetic methodologies for the assembly and functionalisation of peptides and proteins, thereby enabling access to a range of homogeneous, post translationally modified proteins though total chemical synthesis. These research outcomes will expand Australia's research capability and global competitiveness in the field of biotechnology, delivering significant benefits to the third largest manufacturing sector in Australia.

Funded Activity Details

Start Date: 14-01-2019

End Date: 31-03-2023

Funding Scheme: Discovery Projects

Funding Amount: $420,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Organic Chemistry | Organic Chemical Synthesis

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences |

Other Keywords

Expanding Knowledge in the Chemical Sciences | Organic Chemical Synthesis | Organic Chemistry | Proteins and Peptides

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