Discovery Projects - Grant ID: DP190102285

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190102285

Funding Status
Closed

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Funded Activity Summary

Molecular determinants of inflammatory caspase activity upon inflammasomes. Most processes fundamental to life rely on the timely, and regulated, execution of cellular functions. The innate immune system, in which both timing and regulation is paramount, rapidly detects invading microbes and induces a measured and timely antimicrobial response to clear infection. This project aims to address a key knowledge gap by characterising a mechanism for timely and controlled immune system activation and immune cell death via the non-canonical inflammasome. We do not currently understand how some immune pathways are turned on or off. This project will yield fundamental insight into mechanisms of mammalian inflammasome, inflammation and anti-microbial responses.

Funded Activity Details

Start Date: 10-01-2019

End Date: 09-01-2022

Funding Scheme: Discovery Projects

Funding Amount: $495,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Signal Transduction | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Cell Development, Proliferation and Death | Enzymes | Expanding Knowledge in the Biological Sciences | Signal Transduction

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