Discovery Projects - Grant ID: DP190102072

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190102072

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

How tissues generate the peptide hormone angiotensin II. This project aims to investigate how local tissue renin-angiotensin systems operate. A blood-borne renin–angiotensin system (RAS) produces a peptide (AngII) to control blood pressure, and fluid/salt balance. Many tissues, such as the brain and heart, also possess an independent, tissue RAS, but how these function is not well understood. The project will use a model whereby infiltrating macrophages (following damage to the heart) drive the activation of this system to trigger the local generation of AngII. This project addresses the question of where exactly in the heart the RAS components are turned on, how they interact to generate AngII and whether the activation of the local RAS is beneficial or not to cardiac function. The findings should provide critical insights into an important hormonal system.

Funded Activity Details

Start Date: 10-01-2019

End Date: 09-01-2022

Funding Scheme: Discovery Projects

Funding Amount: $445,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology - Systems | Cell Physiology | Biochemistry and Cell Biology not elsewhere classified | Physiology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Animal Physiology - Systems | Biochemistry and Cell Biology not elsewhere classified | Cell Physiology | Expanding Knowledge in the Biological Sciences | Physiology

Related Links