Discovery Projects - Grant ID: DP190101973

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190101973

Funding Status
Active

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Funded Activity Summary

Shear stimulated Brillouin microscopy for cell mechanobiology. This project aims to develop novel technology for non-contact imaging of micro-mechanical properties in cells and tissues to answer fundamental questions of cell mechnanobiology. Based on principles of Brillouin light scattering, the project takes advantage of a radio-frequency lock-in detection scheme. The project will result in a real-time, high-sensitivity, non-contact 3D imaging solution for spatial characterisation of cell's local stiffness and compressibility. This will underpin the advancement of knowledge in the area of cell mechanobiology and the investigation of diseases, where microscale changes in cell mechanical properties lead to cell dysfunction and apoptosis.

Funded Activity Details

Start Date: 01-01-2019

End Date: 30-06-2023

Funding Scheme: Discovery Projects

Funding Amount: $335,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Biochemistry and Cell Biology | Nonlinear Optics and Spectroscopy | Biological Physics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Physical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biological Physics | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Physical Sciences | Nonlinear Optics and Spectroscopy

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