Discovery Projects - Grant ID: DP190101945

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190101945

Funding Status
Active

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Funded Activity Summary

Chemical-biology approaches to pathway selective adenosine receptor ligands. This project aims to develop new chemical-biology tools and approaches for selectively targeting signalling pathways mediated by G protein-coupled receptors (GPCR). GPCRs are an important family of cell surface signalling proteins that are responsible for the regulation of numerous vital physiological functions. The A1 adenosine receptor is an important model and therapeutically relevant GPCR that will be the focus of this project. Compounds known as bitopic ligands, which can interact with distinct binding sites (termed orthosteric and allosteric sites), will be explored as pathway selective agents capable of activating the signalling pathways mediating the desired effect in preference to those producing adverse effects. Longer-term benefits include the identification of bioactive compounds with more selective modes of action and improved safety profiles.

Funded Activity Details

Start Date: 01-07-2019

End Date: 30-06-2023

Funding Scheme: Discovery Projects

Funding Amount: $450,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biologically Active Molecules | Characterisation of Biological Macromolecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry

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