Discovery Projects - Grant ID: DP190101937

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190101937

Funding Status
Active

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Funded Activity Summary

Age-related mechanisms of amino acid signalling in skeletal muscle. This project aims to increase our understanding of the role of glycine receptor-mediated signalling and its metabolism in the amino acid sensing capacity of mTORC1, a key enzyme regulating muscle protein synthesis. Ageing is associated with a progressive decline in skeletal muscle mass, weakness, and impaired regeneration after injury. Impaired anabolic signalling after food intake has been proposed as a key contributor, yet the metabolic pathways responsible for nutrient sensing and regulation of protein synthesis remain unresolved. The project will assess defective amino acid sensing and protein synthesis in old mammals, identifying the role of glycine signalling in these processes. The project expects to underpin development of muscle-specific modulators of muscle homeostasis with broad relevance to Australia’s ageing population.

Funded Activity Details

Start Date: 01-02-2019

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $499,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology - Cell | Medical Biochemistry: Amino Acids and Metabolites | Physiology | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Animal Physiology - Cell | Cell Metabolism | Expanding Knowledge in the Biological Sciences | Medical Biochemistry: Amino Acids and Metabolites | Physiology

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