Discovery Projects - Grant ID: DP190101613

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190101613

Funding Status
Active

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Funded Activity Summary

Molecular mechanisms of novel bacterial copper defense proteins. This project aims to reveal molecular and cellular mechanisms used by bacteria to neutralise the destructive effects of copper. Copper is an essential trace element in living systems. It is toxic to bacteria and so plays a vital role in nutritional immunity. To counteract copper toxicity, bacteria have evolved defense mechanisms. The project will investigate a novel but poorly understood class of bacterial proteins, the suppressor of copper sensitivity proteins, that contribute to this key virulence trait. The expected outcomes will be fundamental new knowledge of metallo-protein diversity, bacterial virulence mechanisms, and membrane protein function with potential impact on health, environment, and biotechnology.

Funded Activity Details

Start Date: 27-03-2019

End Date: 26-03-2022

Funding Scheme: Discovery Projects

Funding Amount: $550,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Enzymes | Expanding Knowledge in the Biological Sciences | Microbiology not elsewhere classified | Structural Biology (incl. Macromolecular Modelling)

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