Discovery Projects - Grant ID: DP190100423

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP190100423

Funding Status
Active

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Funded Activity Summary

RNA surveillance and the initial steps of RNA biogenesis. This project aims to understand the initial steps of RNA biogenesis and how this process is linked to the chromatin environment. Although less than five per cent of our genome encodes proteins, almost the entire genome is transcribed to RNA. A large portion of these transcripts are degraded during the early steps of RNA biogenesis by the RNA surveillance machinery, but the mechanism for the recognition and degradation of these transcripts is not understood. New evidence suggests that the chromatin environment of the transcribed locus plays an important role in this process. This project will lead to significant benefits in the implementation of emerging RNA-based technologies and in understanding how genome stability is maintained.

Funded Activity Details

Start Date: 01-02-2019

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $370,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics) | Gene Expression (incl. Microarray and other genome-wide approaches) | Genome Structure and Regulation | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Epigenetics (incl. Genome Methylation and Epigenomics) | Expanding Knowledge in the Biological Sciences | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics | Genome Structure and Regulation

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