Discovery Projects - Grant ID: DP180103989

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP180103989

Funding Status
Closed

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Funded Activity Summary

Understanding how RNA editing regulates RNA fate. This project aims to address how RNA editing mediated by ADAR1 alters the interactions of targeted RNA with the innate immune sensing system. ADAR1 editing converts adenosine to inosine within double stranded RNA. It is known that this is key to prevent activation of the innate immune sensor MDA5 by endogenous RNA. However, we do not understand why edited RNA is tolerated and unedited RNA is not. This project will generate new knowledge regarding the effect of editing on how endogenous RNA is perceived by the innate immune system.

Funded Activity Details

Start Date: 01-01-2018

End Date: 31-12-2020

Funding Scheme: Discovery Projects

Funding Amount: $425,349.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry and Metabolomics | Medical Biochemistry: Nucleic Acids | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Innate Immunity | Medical Biochemistry and Metabolomics | Medical Biochemistry: Nucleic Acids

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