Discovery Projects - Grant ID: DP180103244

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP180103244

Funding Status
Closed

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Funded Activity Summary

Compressing small peptides for cell absorption. This project aims to understand how to make small structured peptides cell-permeable. Short peptides matching bioactive protein surfaces have no structure in water and do not enter cells, where most biological reactions occur. This project will compress peptides into very small coiled structures and systematically vary cyclic restraints, physicochemical properties and location of components to increase cell uptake by different mechanisms. An expected outcome is new knowledge for predicting structures that make peptides cell-permeable without membrane damage. A new capacity to rationally downsize proteins to small, cell-permeable, structured peptides is anticipated to permit many new biological and industrial applications.

Funded Activity Details

Start Date: 01-01-2018

End Date: 31-12-2020

Funding Scheme: Discovery Projects

Funding Amount: $577,120.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Medicinal and Biomolecular Chemistry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Education and Training not elsewhere classified | Expanding Knowledge in the Biological Sciences |

Other Keywords

Education and Training not elsewhere classified | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry | Proteins and Peptides

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