Discovery Projects - Grant ID: DP180102741

Funded Activity Summary

Bioinorganic chemistry between immune cell and pathogen. This project aims to investigate the bioinorganic chemistry that occurs when immune system cells encounter pathogens and they try to kill one another, or in the case of a pathogen, to also modify the genetics of the mammalian cell to enable its intracellular survival. Pathogenic bacteria and fungi accumulate chromium (Cr) in their membranes and it was recently discovered that Cr is likely to be an important virulence factor. Similarly, Hyperaccummulation of Nickel (Ni) is also involved in virulence. The project will investigate the roles of Cr and Ni in virulence using advanced spectroscopic imaging and biochemical techniques. These insights will provide new knowledge on the innate immune system and may lead to more efficacious treatments for serious infections.

Funded Activity Details

Start Date: 01-01-2018

End Date: 27-02-2021

Funding Scheme: Discovery Projects

Funding Amount: $535,608.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Inorganic Chemistry | Analytical Biochemistry | Bioinorganic Chemistry | Immunological and Bioassay Methods

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Analytical Biochemistry | Bioinorganic Chemistry | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Medical and Health Sciences | Immunological and Bioassay Methods | Inorganic Chemistry

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