Discovery Projects - Grant ID: DP180100805

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP180100805

Funding Status
Closed

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Funded Activity Summary

Molecular Interactions with an antibiotic target in DNA replication. This project aims to develop and use new technologies to address mechanistic aspects of anti-bacterial compounds in development, and of the development of resistance to them. The project will focus on the sliding clamp subunit of the bacterial replicative polymerase by studying its association with many other proteins in vitro and in vivo, using novel techniques in solid-state NMR, single-molecule fluorescence and molecular microbiology. The outcomes are expected to be an increased understanding of bacterial DNA replication and mechanisms of antibiotic action and resistance. This project expects to generate new knowledge to assist in combatting antibiotic resistance in Gram-negative bacterial pathogens.

Funded Activity Details

Start Date: 01-01-2018

End Date: 07-02-2021

Funding Scheme: Discovery Projects

Funding Amount: $534,573.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Medicinal and Biomolecular Chemistry | Structural Biology (incl. Macromolecular Modelling) | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Treatments (e.g. Antibiotics) | Infectious Diseases |

Other Keywords

Biologically Active Molecules | Human Pharmaceutical Treatments (e.g. Antibiotics) | Infectious Diseases | Medicinal and Biomolecular Chemistry | Proteins and Peptides | Structural Biology (incl. Macromolecular Modelling)

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