Discovery Projects - Grant ID: DP180100785

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP180100785

Funding Status
Active

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Funded Activity Summary

Mixing the jigsaw pieces of natural products: new molecules-new properties. This project aims to examine the capacity of exploiting the bacterial biosynthetic machinery to fast-track access to analogues of natural products. Due to increased drug resistance, new reservoirs of natural products are needed for evaluation as future drugs. Desferrioxamine B will be used as a model natural product to establish the biosynthesis of new analogues in bacterial culture supplemented with unsaturated, fluorinated or deuterated building blocks. The intended outcomes are to deliver advances in methods for generating structurally diverse pools of natural products, new label-free probes, knowledge of natural product biosynthesis, and excellence in training research students in frontier methods in chemical biology and drug discovery.

Funded Activity Details

Start Date: 01-01-2018

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $416,584.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Natural Products Chemistry | Inorganic Chemistry | Bioinorganic Chemistry | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences |

Other Keywords

Bioinorganic Chemistry | Biologically Active Molecules | Expanding Knowledge in the Chemical Sciences | Inorganic Chemistry | Natural Products Chemistry

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