Discovery Projects - Grant ID: DP170104691

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP170104691

Funding Status
Closed

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Funded Activity Summary

The molecular mechanism of action of bacterial epigenetic regulators. This project aims to determine the mechanisms of action of a class of bacterial epigenetic regulators. Many bacteria exhibit phase variable expression of genes (random, high frequency on/off switching of expression), typically due to simple DNA repeats within the gene(s) that encode them. Many bacterial species contain phase variable DNA methyltransferases that regulate epigenetics and control expression of distinct sets of proteins (phasevarions) via variable methylation of the genome. The precise mechanism of action of these regulators is unknown. Characterisation of these systems will provide better understanding of bacterial gene regulation and adaptation, which will inform biotechnology and vaccine development and could contribute to economic and health advancements.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $428,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics) | Microbial Genetics | Microbiology | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Bacteriology | Epigenetics (incl. Genome Methylation and Epigenomics) | Expanding Knowledge in the Biological Sciences | Microbial Genetics | Microbiology

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