Discovery Projects - Grant ID: DP170104386

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP170104386

Funding Status
Closed

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Funded Activity Summary

Unrestricted antigen recognition by T lymphocytes. This project aims to investigate the unrestricted T cell repertoire; the molecular and structural basis of antigen recognition by unrestricted T cells; and the development of unrestricted T cells. T lymphocytes typically are restricted to detecting foreign molecules (antigens) on the cell membrane in association with specialised antigen-presenting molecules encoded within the highly polymorphic major histocompatibility (MHC) locus (MHC restriction). T lymphocytes that can recognise antigens in the absence of MHC or MHC like molecules challenges a major paradigm in the field of immunology. As T cell based therapy underpins treatments for cancer and infection, new mechanisms of T cell activation that are independent of patient genotype should ultimately create opportunities for therapeutic and commercial development, leading to both health and economic benefits.

Funded Activity Details

Start Date: 01-01-2017

End Date: 30-06-2020

Funding Scheme: Discovery Projects

Funding Amount: $428,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Immunology not elsewhere classified | Immunology

ANZSRC Socio-Economic Objective (SEO)

Health not elsewhere classified |

Other Keywords

Cellular Immunology | Health not elsewhere classified | Immunology | Immunology not elsewhere classified

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