Discovery Projects - Grant ID: DP170104046

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP170104046

Funding Status
Closed

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Funded Activity Summary

The early structural assembly of high-density lipoproteins. This project aims to study the interaction between proteins and lipids, a fundamental aspect of cellular processes in all organisms. Lipid binding by apoA-I forms high-density lipoproteins (HDL) in the bloodstream, which removes cholesterol from the body. This project will define the types of lipids that bind first to the apolipoprotein (apo) A-I and the structural mechanisms of this process. The conformation of lipid binding proteins often changes during lipid binding. However, the structural mechanisms and conformational rearrangements are poorly understood. This project expects to understand the function of HDL and the structural mechanisms of lipid binding proteins in general. The results will have far-reaching applications in biology, human health, and biotechnology, including food and biopharmaceutical processing.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2020

Funding Scheme: Discovery Projects

Funding Amount: $379,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Analytical Biochemistry | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Structural Biology (incl. Macromolecular Modelling)

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