Discovery Projects - Grant ID: DP170103631

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP170103631

Funding Status
Closed

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Funded Activity Summary

A molecular investigation into the naïve T cell repertoire. This project aims to interrogate the relationship between T cell receptor (TCR) recognition modes and T cell recruitment and activation. CD8+ T cells are important for adaptive immunity. Their recognition, via TCR, of peptides bound to MHC class I antigen-presenting molecules (pMHCI), initiates a signalling cascade which activates T cells effector functions. All structural information on TCR recognition of pMHCI is based on TCRs prevalent in immune responses, and all recognise pMHCI using a conserved orientation. This project aims to use this observation to study the relationship between TCR recognition modes and T cell recruitment and activation.

Funded Activity Details

Start Date: 01-03-2017

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $548,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Signal Transduction | Biochemistry and Cell Biology not elsewhere classified | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy

Other Keywords

Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Signal Transduction | Structural Biology (incl. Macromolecular Modelling)

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