Discovery Projects - Grant ID: DP170103539

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP170103539

Funding Status
Closed

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Funded Activity Summary

Mechanisms of gene regulation. This project aims to determine the molecular basis of specific gene targeting. Transcription factor complexes regulate gene expression by binding to DNA at specific sites, modifying and looping chromatin, and recruiting the basal transcription machinery. Using blood cell transcription factor complexes as a model, this project will reveal interactions between sets of proteins that fine-tune DNA binding and recruit accessory proteins that regulate gene expression. The mechanistic detail provided is expected to inform the artificial up- or down-regulation of genes in biotechnological applications and ultimately treat disease which have a genetic component.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2020

Funding Scheme: Discovery Projects

Funding Amount: $399,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Systems Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Structural Biology (incl. Macromolecular Modelling) | Systems Biology

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