Discovery Projects - Grant ID: DP170103070

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP170103070

Funding Status
Closed

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Funded Activity Summary

Chromatin structure and pervasive transcription. This project aims to understand mechanisms that repress pervasive transcription and to identify chromatin characteristics that repress transcription initiation outside the promoter regions. Chromatin characteristics, such as position, occupancy and turnover-rate of nucleosomes, establish an elaborate genomic indexing mechanism, which defines functional units in the genome. Defects in this process increase pervasive transcription, toxic accumulation of non-coding transcripts and genomic instability. This work aims to understand eukaryotic genome organisation and may have long-term therapeutic implications for cancer and ageing-related diseases.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $428,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics) | Gene Expression (incl. Microarray and other genome-wide approaches) | Genome Structure and Regulation | Genetics

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Neurodegenerative Disorders Related to Ageing | Cancer and Related Disorders |

Other Keywords

Cancer and Related Disorders | Cardiovascular System and Diseases | Epigenetics (incl. Genome Methylation and Epigenomics) | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics | Genome Structure and Regulation | Neurodegenerative Disorders Related to Ageing

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