Discovery Projects - Grant ID: DP170100823

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP170100823

Funding Status
Closed

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Funded Activity Summary

How ribosomal protein loss affects cell fate. This project aims to challenge the dogma that the ribosome behaves only as a ‘‘house-keeper’’. Ribosomal protein (RP) mutations should, and often do, result in reduced cell growth and stunted animal development. Depletion of RPs in Drosophila blood cells impair stem cells and cause massive tissue overgrowth. This suggests RPs are involved in cell fate determination, which this project will research using genetic models. As ribosomal function is fundamental to the development of all living organisms, this work could have wide implications for understanding all biology – from microbes, insects and plants to humans.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $418,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination) | Gene Expression (incl. Microarray and other genome-wide approaches) | Biochemistry and Cell Biology | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Biochemistry and Cell Biology | Cell Development, Proliferation and Death | Developmental Genetics (incl. Sex Determination) | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Gene Expression (incl. Microarray and other genome-wide approaches)

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