Discovery Projects - Grant ID: DP160104858

Funded Activity Summary

Sprouting Angiogenesis and its Role in Development of Chamber Myocardium. The project aims to investigate how heart chambers form by testing the hypothesis that morphogenesis of the muscular walls of the heart is regulated during development by a Notch signalling-dependent process akin to angiogenic sprouting in other vascular beds. The project outcomes may have implications for diagnosis of congenital heart disease and for the fields of cardiac tissue engineering and regeneration. The project plans to elucidate cellular and molecular pathways underlying heart chamber development in mice using contemporary genetic methods, molecular embryology and imaging. Benefits may include a new framework for understanding heart development and disease, and the future application of this knowledge to translational cardiology.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $467,400.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination) | Gene Expression (incl. Microarray and other genome-wide approaches) | Cell Development, Proliferation and Death | Genetics

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Expanding Knowledge in the Biological Sciences |

Other Keywords

Cardiovascular System and Diseases | Cell Development, Proliferation and Death | Developmental Genetics (incl. Sex Determination) | Expanding Knowledge in the Biological Sciences | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics

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