Discovery Projects - Grant ID: DP160104411

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160104411

Funding Status
Closed

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Funded Activity Summary

Voltage-dependent structural changes in voltage-gated sodium channels. This project aims to provide insights into the structural rearrangements experienced by Nav channels, which are key components of animal nervous systems. Voltage-gated sodium (Nav) channels initiate action potentials in excitable cells. They open in response to membrane depolarisation then rapidly inactivate. Eukaryotic Nav channels contain four unique voltage-sensor domains (VSDs) that control how the channel responds to membrane potential changes. Recently reported crystal structures of bacterial Nav channels have greatly advanced the field, but these channels contain four identical VSDs and have different inactivation properties. Thus, much remains to be learnt about the conformational plasticity of eukaryotic Nav channel VSDs. The project plans to use animal toxins to capture eukaryotic VSDs in defined states of the gating cycle for detailed structural analysis using nuclear magnetic resonance and X-ray crystallography.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $435,700.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Mineralogy and Crystallography | Proteins and Peptides | Structural Chemistry and Spectroscopy | Medicinal and Biomolecular Chemistry

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Products not elsewhere classified | Crop Protection Chemicals | Expanding Knowledge in the Biological Sciences |

Other Keywords

Crop Protection Chemicals | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Products not elsewhere classified | Medicinal and Biomolecular Chemistry | Mineralogy and Crystallography | Proteins and Peptides | Structural Chemistry and Spectroscopy

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