Discovery Projects - Grant ID: DP160103294

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160103294

Funding Status
Closed

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Funded Activity Summary

Autotransporter folding: insights advancing recombinant protein production. Imagine a world in which any protein could be produced using a single production platform. This project aims to make this a reality by reengineering autotransporters, a large family of bacterial virulence factors with a modular structure that makes them amenable to rational design. The project plans to examine the structures and folding behaviour of autotransporters and reengineered derivatives fused to target heterologous proteins using biochemical, biophysical, and structural methods. It is expected that this project will provide fundamental insights into factors that dictate autotransporter folding and stability, which may enhance recombinant protein production and drive discovery of strategies to prevent autotransporter-mediated infection.

Funded Activity Details

Start Date: 01-04-2016

End Date: 02-02-2020

Funding Scheme: Discovery Projects

Funding Amount: $346,800.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Receptors and Membrane Biology | Nanobiotechnology | Microbiology | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Human Biological Preventatives (e.g. Vaccines) | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology |

Other Keywords

Bacteriology | Expanding Knowledge in Technology | Expanding Knowledge in the Biological Sciences | Human Biological Preventatives (e.g. Vaccines) | Microbiology | Nanobiotechnology | Receptors and Membrane Biology

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