Discovery Projects - Grant ID: DP160103134

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160103134

Funding Status
Closed

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Funded Activity Summary

Characterisation of membrane protein ubiquitination by MARCH ligases. The goal of the project is to understand how a family of enzymes called MARCHs regulate expression and localisation of immunoregulatory receptors within cells by post-translational addition of a small protein tag called Ubiquitin. The aims are to decipher the ubiquitination patterns produced by the MARCHs; identify the E2 ligases used by the MARCHs to produce distinct Ub codes; and apply a new proteomic pipeline to identify novel representative MARCH substrates in mice deficient in six different MARCHs. It is anticipated the project will reveal novel insights into a fundamental cell biological process of major significance for regulation of protein expression and trafficking in cells of the immune system.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $633,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Biochemistry and Cell Biology | Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Protein Trafficking | Receptors and Membrane Biology

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