Discovery Projects - Grant ID: DP160102766

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160102766

Funding Status
Closed

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Funded Activity Summary

Moonlighting from sugar to metal. This project intends to use integrated genetics, biochemistry and omics to decipher the roles of the highly conserved OST3 proteins, which have been implicated in the disparate functions of regulating protein glycosylation and transporting magnesium. The project plans to detail the role of OST3 proteins in regulating mammalian glycosylation and reconstruct the vertebrate co-evolutionary trajectory of OST3 protein–substrate interactions. It also aims to identify and characterise the regulation, mechanisms and metabolic consequences of OST3 protein-mediated magnesium transport. These outcomes may provide insights into eukaryotic biology, and allow advances in engineered systems for glycoprotein production and modulating cellular metabolism with potential research and therapeutic utility.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $394,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Receptors and Membrane Biology | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy |

Other Keywords

Biochemistry and Cell Biology | Cell Metabolism | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Receptors and Membrane Biology

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