Discovery Projects - Grant ID: DP160102681

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160102681

Funding Status
Closed

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Funded Activity Summary

Rapid, ultra-sensitive protein structure elucidation by mass spectrometry. This project seeks to develop a method for rapidly discovering classes of molecules that bind to unique sites on proteins. The development of new pharmaceuticals is frequently delayed by the time and resources required to identify the sites that new chemical entities bind to protein targets. A recent discovery has resulted in the ability to completely characterise large protein sequences directly from single mass spectra. This project aims to leverage this breakthrough by developing a rapid new approach for revealing ligand-protein binding sites using whole-protein mass spectrometry. This would enable novel sites of interactions between molecules and protein targets to be discovered rapidly with high sensitivity. In turn, this would allow the efficient design of next-generation classes of bioactive molecules.

Funded Activity Details

Start Date: 01-01-2016

End Date: 30-06-2019

Funding Scheme: Discovery Projects

Funding Amount: $299,700.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Analytical Chemistry | Structural Chemistry and Spectroscopy | Analytical Spectrometry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Analytical Chemistry | Analytical Spectrometry | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Structural Chemistry and Spectroscopy

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