Discovery Projects - Grant ID: DP160102435

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160102435

Funding Status
Closed

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Funded Activity Summary

The structure in four-dimensions of a mammalian nuclear body. The project aims to develop a working model of a micron-sized molecular machine implicated in numerous aspects of gene regulation. Bodies in the mammalian cell nucleus are larger than macromolecular complexes and smaller than organelles. Recent developments in structural, molecular and cell biology are allowing us to begin to interpret their structure-function relationships. This project capitalises on a wealth of structural and functional data on nuclear bodies termed paraspeckles with the aim of developing a structural model. It aims to track tens of proteins and long non-coding RNA from paraspeckles as they proceed through the cell cycle, by combining genome engineering, super-resolution microscopy, proteomics and in vitro interaction studies.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $408,800.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Systems Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Structural Biology (incl. Macromolecular Modelling) | Systems Biology

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