Discovery Projects - Grant ID: DP160102063

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160102063

Funding Status
Closed

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Funded Activity Summary

Profiling tissue protein, elemental ions and nanoparticle distributions. This project aims to investigate protein-protein interactions that are crucial to homeostatic cell signalling and viability in a changing tissue environment. The central goal is to develop and validate protocols to combine cutting-edge tissue imaging modalities to map and characterise tissue distributions of native and modified proteins, elemental ions and pharmacological agents including nanoparticles and nanovehicles. The aim is to use novel tissue scanning mass spectrometry techniques in conjunction with X-ray-based microprobe spectroscopy and advanced multi-parameter cytometry to identify spatial distributions of proteins, ions and drugs in tissues. This approach may provide new information about the maintenance of homeostatic control and the content, distribution and potential metabolism of drugs or nanoparticles within biological tissues.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-07-2019

Funding Scheme: Discovery Projects

Funding Amount: $345,100.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Synchrotrons; Accelerators; Instruments and Techniques | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Basic Pharmacology | Biochemistry and Cell Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Basic Pharmacology | Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Synchrotrons; Accelerators; Instruments and Techniques

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