Discovery Projects - Grant ID: DP160101970

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160101970

Funding Status
Closed

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Funded Activity Summary

Allosteric and Bitopic Ligands Acting at G Protein-Coupled Receptors. This project seeks to gain a more detailed understanding of the mechanisms of the function of G protein-coupled receptors (GPCRs) using novel chemical tools. GPCRs are the largest group of cell surface signalling proteins and are responsible for the regulation of numerous vital physiological functions. They are the target of over 30 per cent of currently used pharmaceuticals. Despite their importance, much remains to be learned about the regulation of GPCRs by small molecules. This project aims to address this gap by focusing on novel regions on these proteins, termed allosteric sites, to explore novel modes of GPCR regulation which may offer the potential of identifying pathway selective agents.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $667,850.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Neurodegenerative Disorders Related to Ageing | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biologically Active Molecules | Expanding Knowledge in the Biological Sciences | Neurodegenerative Disorders Related to Ageing | Receptors and Membrane Biology

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