Discovery Projects - Grant ID: DP160101721

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160101721

Funding Status
Closed

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Funded Activity Summary

A conserved pathway of cell death in response to invading DNA. This project aims to characterise molecular details of a new pathway of foreign DNA recognition and rapid cell death. Recognition of foreign DNA is a key means by which both bacteria and eukaryotic cells can detect infections, as well as guard their own genome. Eukaryotic cell DNA is sequestered in the nucleus and organelles, and any DNA found in the cytosol is a danger signal. The project proposes that cytosolic DNA-induced cell death is a fundamental eukaryotic defensive response, but surprisingly, the known pathway is restricted to macrophages of some mammals. Project outcomes may be applied to protein expression yield in biotechnology or advances in gene therapy.

Funded Activity Details

Start Date: 01-01-2016

End Date: 30-11-2019

Funding Scheme: Discovery Projects

Funding Amount: $356,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Immunology | Biochemistry and Cell Biology | Evolutionary Biology not elsewhere classified | Cell Development, Proliferation and Death |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Infectious Diseases

Other Keywords

Animal Immunology | Biochemistry and Cell Biology | Cell Development, Proliferation and Death | Evolutionary Biology not elsewhere classified | Expanding Knowledge in the Biological Sciences | Infectious Diseases

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