Discovery Projects - Grant ID: DP160101573

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160101573

Funding Status
Closed

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Funded Activity Summary

Defining the membrane protein cargo transported by Retromer. This project aims to define the role of Retromer, a protein machine that directs the organisation and movement of proteins within the cell. The function of proteins is dependent on how they travel through the various regions or compartments within the cell. One intracellular compartment, termed endosomes, is central to this dynamic process. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling and development. Endosomal transport occurs within membrane domains and membrane vesicular carriers formed by Retromer. This project aims to define the transmembrane proteins sorted by the distinct retromer complexes that form within the cell and the sorting signals essential for their correct trafficking and localisation.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2020

Funding Scheme: Discovery Projects

Funding Amount: $468,100.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Biochemistry and Cell Biology | Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Protein Trafficking | Receptors and Membrane Biology

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